The rapid advancement of Large Language Models (LLMs) has enabled the generation of highly realistic synthetic data. We identify a new vulnerability, LLMs generating convincing career trajectories in fake resumes and explore effective detection methods. To address this challenge, we construct a dataset of machine-generated career trajectories using LLMs and various methods, and demonstrate that conventional text-based detectors perform poorly on structured career data. We propose CareerScape, a novel heterogeneous, hierarchical multi-layer graph framework that models career entities and their relations in a unified global graph built from genuine resumes. Unlike conventional classifiers that treat each instance independently, CareerScape employs a structure-aware framework that augments user-specific subgraphs with trusted neighborhood information from a global graph, enabling the model to capture both global structural patterns and local inconsistencies indicative of synthetic career paths. Experimental results show that CareerScape outperforms state-of-the-art baselines by 5.8-85.0% relatively, highlighting the importance of structure-aware detection for machine-generated content.