We present \texttt{secml}, an open-source Python library for secure and explainable machine learning. It implements the most popular attacks against machine learning, including test-time evasion attacks to generate adversarial examples against deep neural networks and training-time poisoning attacks against support vector machines and many other algorithms. These attacks enable evaluating the security of learning algorithms and the corresponding defenses under both white-box and black-box threat models. To this end, \texttt{secml} provides built-in functions to compute security evaluation curves, showing how quickly classification performance decreases against increasing adversarial perturbations of the input data. \texttt{secml} also includes explainability methods to help understand why adversarial attacks succeed against a given model, by visualizing the most influential features and training prototypes contributing to each decision. It is distributed under the Apache License 2.0 and hosted at \url{https://github.com/pralab/secml}.