Machine learning (ML) classifiers are vulnerable to adversarial examples. An adversarial example is an input sample which is slightly modified to induce misclassification in an ML classifier. In this work, we investigate white-box and grey-box evasion attacks to an ML-based malware detector and conduct performance evaluations in a real-world setting. We compare the defense approaches in mitigating the attacks. We propose a framework for deploying grey-box and black-box attacks to malware detection systems.