The use of machine learning and intelligent systems has become an established practice in the realm of malware detection and cyber threat prevention. In an environment characterized by widespread accessibility and big data, the feasibility of malware classification without the use of artificial intelligence-based techniques has been diminished exponentially. Also characteristic of the contemporary realm of automated, intelligent malware detection is the threat of adversarial machine learning. Adversaries are looking to target the underlying data and/or algorithm responsible for the functionality of malware classification to map its behavior or corrupt its functionality. The ends of such adversaries are bypassing the cyber security measures and increasing malware effectiveness. The focus of this research is the design of an intelligent systems approach using machine learning that can accurately and robustly classify malware under adversarial conditions. Such an outcome ultimately relies on increased flexibility and adaptability to build a model robust enough to identify attacks on the underlying algorithm.