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Abstract
Survival Analysis (SA) models the time until an event occurs, with
applications in fields like medicine, defense, finance, and aerospace. Recent
research indicates that Neural Networks (NNs) can effectively capture complex
data patterns in SA, whereas simple generalized linear models often fall short
in this regard. However, dataset uncertainties (e.g., noisy measurements, human
error) can degrade NN model performance. To address this, we leverage advances
in NN verification to develop training objectives for robust, fully-parametric
SA models. Specifically, we propose an adversarially robust loss function based
on a Min-Max optimization problem. We employ CROWN-Interval Bound Propagation
(CROWN-IBP) to tackle the computational challenges inherent in solving this
Min-Max problem. Evaluated over 10 SurvSet datasets, our method, Survival
Analysis with Adversarial Regularization (SAWAR), consistently outperforms
baseline adversarial training methods and state-of-the-art (SOTA) deep SA
models across various covariate perturbations with respect to Negative Log
Likelihood (NegLL), Integrated Brier Score (IBS), and Concordance Index (CI)
metrics. Thus, we demonstrate that adversarial robustness enhances SA
predictive performance and calibration, mitigating data uncertainty and
improving generalization across diverse datasets by up to 150% compared to
baselines.