Several recent works focused on the best practices for applying machine learning to cybersecurity. In the context of malware, TESSERACT highlighted the impact of concept drift on detection performance and suggested temporal and spatial constraints to be enforced to ensure realistic time-aware evaluations, which have been adopted by the community. In this paper, we demonstrate striking discrepancies in the performance of learning-based malware detection across the same time frame when evaluated on two representative Android malware datasets used in top-tier security conferences, both adhering to established sampling and evaluation guidelines. This questions our ability to understand how current state-of-the-art approaches would perform in realistic scenarios. To address this, we identify five novel temporal and spatial bias factors that affect realistic evaluations. We thoroughly evaluate the impact of these factors in the Android malware domain on two representative datasets and five Android malware classifiers used or proposed in top-tier security conferences. For each factor, we provide practical and actionable recommendations that the community should integrate in their methodology for more realistic and reproducible settings.