These labels were automatically added by AI and may be inaccurate. For details, see About Literature Database.
Abstract
The proliferation of healthcare data has expanded opportunities for
collaborative research, yet stringent privacy regulations hinder pooling
sensitive patient records. We propose a \emph{multiparty homomorphic
encryption-based} framework for \emph{privacy-preserving federated
Kaplan--Meier survival analysis}, offering native floating-point support, a
theoretical model, and explicit reconstruction-attack mitigation. Compared to
prior work, our framework ensures encrypted federated survival estimates
closely match centralized outcomes, supported by formal utility-loss bounds
that demonstrate convergence as aggregation and decryption noise diminish.
Extensive experiments on the NCCTG Lung Cancer and synthetic Breast Cancer
datasets confirm low \emph{mean absolute error (MAE)} and \emph{root mean
squared error (RMSE)}, indicating negligible deviations between encrypted and
non-encrypted survival curves. Log-rank and numerical accuracy tests reveal
\emph{no significant difference} between federated encrypted and non-encrypted
analyses, preserving statistical validity. A reconstruction-attack evaluation
shows smaller federations (2--3 providers) with overlapping data between the
institutions are vulnerable, a challenge mitigated by multiparty encryption.
Larger federations (5--50 sites) degrade reconstruction accuracy further, with
encryption improving confidentiality. Despite an 8--19$\times$ computational
overhead, threshold-based homomorphic encryption is \emph{feasible for
moderate-scale deployments}, balancing security and runtime. By providing
robust privacy guarantees alongside high-fidelity survival estimates, our
framework advances the state-of-the art in secure multi-institutional survival
analysis.